The decline in anti-tumor immunity with aging is speculated to be a significant factor contributing to the high incidence of cancer in elderly individuals. Leveraging our expertise in studying immunometabolism (Vaeth* and Maus* et al. Immunity, 2017), and the metabolism of aging (Maus et al. Nature Metabolism, 2023), our research in this area focuses on investigating how age-related disruption in iron metabolism is associated with decreased tumor surveillance and T cell exhaustion. Our objective is to identify approaches capable of rejuvenating the metabolic microenvironment where tumor surveillance and anti-tumor immunity occur, to thereby prevent and treat cancer.